知识库文章

Differences Between Peptide and Glycopeptide Workflows in SCIEX OS

This article describes the key differences between Peptide and Glycopeptide workflows in SCIEX OS. While most acquisition parameters remain identical, specific adjustments are applied in the Glycopeptide workflow to improve transmission, detection, and fragmentation of higher-mass glycopeptide species

How to use the "Find X peaks" feature while avoiding potential integration issues in SCIEX OS.

This article explains how to use the "Find X peaks" feature in SCIEX OS and why some intense peaks are not integrated despite using this feature.

How to check the presence of a charging effect on a specific compound ?

Charging effect tests allow verification of the fouling state of a mass spectrometer. These tests are generally performed using a calibrator, such as PPG. However, charging effects may not be visible on the calibrator but may exist for specific compounds. This article describes how to perform a charging effect test on a specific compound.

Why can the ejection time in the results table in Analytics (Sciex OS Software) differ to the ejection time displayed in the auto exported .txt files?

When performing analyses with an Echo-MS and Sciex OS, the ejection time displayed in results tables can differ to the time displayed in the auto exported .txt files.

Diagnosing signal instability when processing data in Analyst®, MultiQuant™, or SCIEX OS software

Signal instability typically results in fluctuating responses from samples with the same level of analytes, causing significant variability in measured outcomes. Due to random fluctuations in peak area, signal instability could also affect linearity and recovery. If signal instability is observed while processing data in Analyst®, MultiQuant, or SCIEX OS software, it's possible to diagnose the source of signal instability by evaluating: 1) sample and material preparation, 2) LCMS method instability, and 3) instrument issues.

How to check that the heaters located in the source of the MS are working ?

This article describes the procedure to follow to check that the heaters located in the source (Turbo V ion source and IonDrive Turbo V ion source) of the mass spectrometer are working. This procedure describes the procedures for both, Analyst® software and SCIEX OS software.